Htr4^tm1Comp
Targeted Allele Detail

Summary

• Symbol: Htr4^tm1Comp
• Name: 5 hydroxytryptamine (serotonin) receptor 4; targeted mutation 1, Valerie Compan
• MGI ID: MGI:3027491
• Gene: Htr4 Location: Chr18:62457275-62629648 bp, + strand Genetic Position: Chr18, 35.1 cM, cytoband D3
• Alliance: Htr4^tm1Comp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87451
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the third transmembrane domain was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Autoradiography of frontal brain sections indicated an absence of functional protein in homozygous mutant brain tissue. (J:87451)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr4 Mutation: 31 strains or lines available

References

• Original: J:87451 Compan V, et al., Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci. 2004 Jan 14;24(2):412-9
• All: 13 reference(s)