Cables1^tm1Lrz
Targeted Allele Detail

Summary

• Symbol: Cables1^tm1Lrz
• Name: CDK5 and Abl enzyme substrate 1; targeted mutation 1, Lawrence R Zukerberg
• MGI ID: MGI:3027499
• Synonyms: Cables^-, Cables1^tm1Brue
• Gene: Cables1 Location: Chr18:11972600-12078681 bp, + strand Genetic Position: Chr18, 5.88 cM, cytoband A2
• Alliance: Cables1^tm1Lrz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87478
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb sequence fragment, encompassing all of exon 1, was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the start codon, 617 bp of 5' untranslated sequence, and the splice donor site of intron 1. Protein was undetected in homozygous mutant mice by Western blot analysis of endometrial tissue. (J:87478)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cables1^tm1Lrz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cables1 Mutation: 40 strains or lines available

References

• Original: J:87478 Zukerberg LR, et al., Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Cancer Res. 2004 Jan 1;64(1):202-8
• All: 4 reference(s)