Slc1a6^tm1Dbe
Targeted Allele Detail

Summary

• Symbol: Slc1a6^tm1Dbe
• Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; targeted mutation 1, Dwight E Bergles
• MGI ID: MGI:3027689
• Synonyms: EAAT4^-
• Gene: Slc1a6 Location: Chr10:78616330-78650599 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Slc1a6^tm1Dbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87447
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7, which encodes the sixth transmembrane segment, was replaced with a neomycin resistance gene. Lack of transcript was demonstrated by PCR and absence of protein was confirmed by Western blot analysis and immunocytochemistry. (J:87447)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc1a6 Mutation: 55 strains or lines available

References

• Original: J:87447 Huang YH, et al., Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. J Neurosci. 2004 Jan 7;24(1):103-11
• All: 6 reference(s)