Btla^tm1Kmm
Targeted Allele Detail

Summary

• Symbol: Btla^tm1Kmm
• Name: B and T lymphocyte associated; targeted mutation 1, Kenneth M Murphy
• MGI ID: MGI:3027713
• Synonyms: BTLA-
• Gene: Btla Location: Chr16:45043121-45073258 bp, + strand Genetic Position: Chr16, 29.52 cM
• Alliance: Btla^tm1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region containing exons 3, 4 and 5 was replaced with a neomycin selection cassette through homologous recombination. Northern blot analysis on splenocytes derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:84084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Btla Mutation: 30 strains or lines available

References

• Original: J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
• All: 24 reference(s)