Prg2^tm1Nal
Targeted Allele Detail

Summary

• Symbol: Prg2^tm1Nal
• Name: proteoglycan 2, bone marrow; targeted mutation 1, Nancy A Lee
• MGI ID: MGI:3027719
• Synonyms: MBP-, mMBP-1^-
• Gene: Prg2 Location: Chr2:84810805-84813976 bp, + strand Genetic Position: Chr2, 49.45 cM
• Alliance: Prg2^tm1Nal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65655
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and 4 were replaced with a PGK-neomycin cassette. The replaced sequence includes sequences encoding the signal sequence, propolypeptide, and N-terminal 54 amino acids. RT-PCR demonstrated the absence of transcript. (J:65655)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prg2 Mutation: 22 strains or lines available

References

• Original: J:65655 Denzler KL, et al., Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J Immunol. 2000 Nov 15;165(10):5509-17
• All: 13 reference(s)