Vnn1^tm1Pna
Targeted Allele Detail

Summary

• Symbol: Vnn1^tm1Pna
• Name: vanin 1; targeted mutation 1, Philippe Naquet
• MGI ID: MGI:3027932
• Synonyms: V1^-, Vanin-1 -
• Gene: Vnn1 Location: Chr10:23770586-23781241 bp, + strand Genetic Position: Chr10, 11.33 cM, cytoband A1-B2
• Alliance: Vnn1^tm1Pna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65449
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a PGK neomycin cassette in reverse orientation. Northern blot analysis of mRNA from kidney and RT-PCR confirmed the absence of transcript while Western blot analysis and immunohistochemistry demonstrated the absence of protein. (J:65449)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vnn1 Mutation: 41 strains or lines available

Notes

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References

• Original: J:65449 Pitari G, et al., Pantetheinase activity of membrane-bound vanin-1: lack of free cysteamine in tissues of vanin-1 deficient mice. FEBS Lett. 2000 Oct 20;483(2-3):149-54
• All: 15 reference(s)