Pcyt1a^tm1Irt
Targeted Allele Detail

Summary

• Symbol: Pcyt1a^tm1Irt
• Name: phosphate cytidylyltransferase 1, choline, alpha isoform; targeted mutation 1, Ira Tabas
• MGI ID: MGI:3027956
• Synonyms: CT alpha flox
• Gene: Pcyt1a Location: Chr16:32249739-32293883 bp, + strand Genetic Position: Chr16, 22.69 cM
• Alliance: Pcyt1a^tm1Irt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 330 bp upstream of exon 4. At the same time, a floxed neomycin cassette was inserted in intron 5. (J:65639)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcyt1a Mutation: 28 strains or lines available

References

• Original: J:65639 Zhang D, et al., Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. MOLECULAR GENETIC EVIDENCE THAT THE INDUCTION OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN FREE CHOLESTEROL-LOADED MACROPHAGES IS AN ADAPTIVE RESPONSE [In Process Citation]. J Biol Chem. 2000 Nov 10;275(45):35368-76
• All: 14 reference(s)