Fgf3^tm1Sng
Targeted Allele Detail

Summary

• Symbol: Fgf3^tm1Sng
• Name: fibroblast growth factor 3; targeted mutation 1, Thomas Schimmang
• MGI ID: MGI:3027990
• Synonyms: Fgf3^-
• Gene: Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fgf3^tm1Sng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87221
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1b, 2, and 3 were replaced by a loxP site, an Fgf3 cDNA and a floxed neomycin resistance gene. Heterozygous mice were then mated to deleter-cre mice to remove the cDNA and neomycin insert. Absence of transcripts was confirmed by RNA in situ hybridization. (J:87221)

Expression

In Mice Carrying this Mutation:	18 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf3 Mutation: 16 strains or lines available

References

• Original: J:87221 Alvarez Y, et al., Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003 Dec;130(25):6329-38
• All: 12 reference(s)