Gpr37^tm1Gtva
Targeted Allele Detail

Summary

• Symbol: Gpr37^tm1Gtva
• Name: G protein-coupled receptor 37; targeted mutation 1, Glauco Tocchini-Valentini
• MGI ID: MGI:3027992
• Synonyms: Gpr37^flox
• Gene: Gpr37 Location: Chr6:25668522-25689979 bp, - strand Genetic Position: Chr6, 11.65 cM
• Alliance: Gpr37^tm1Gtva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91390
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was inserted in intron 1. A properly targeted ES cell clone was transfected with pCre-Pac in vitro expression vector which eliminated the floxed neomycin gene and left exon 1 flanked by loxP sites. (J:91390)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr37 Mutation: 34 strains or lines available

References

• Original: J:91390 Marazziti D, et al., Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10189-94
• All: 1 reference(s)