Gpr37^tm2Gtva
Targeted Allele Detail

Summary

• Symbol: Gpr37^tm2Gtva
• Name: G protein-coupled receptor 37; targeted mutation 2, Glauco Tocchini-Valentini
• MGI ID: MGI:3027995
• Synonyms: Gpr^-
• Gene: Gpr37 Location: Chr6:25668522-25689979 bp, - strand Genetic Position: Chr6, 11.65 cM
• Alliance: Gpr37^tm2Gtva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91390
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Male Gpr37^flox/+ mice were crossed to female mice carrying the Tg(CMV-cre)1Cgn transgene. Cre expression resulted in excision of exon 1. Absence of transcript in the resulting mice was verified by Northern blot analysis. (J:91390)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr37 Mutation: 34 strains or lines available

References

• Original: J:91390 Marazziti D, et al., Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10189-94
• All: 7 reference(s)