Gnai1^tm1Drs
Targeted Allele Detail

Summary

• Symbol: Gnai1^tm1Drs
• Name: G protein subunit alpha i1; targeted mutation 1, Daniel R Storm
• MGI ID: MGI:3028010
• Synonyms: Gia1 ^-
• Gene: Gnai1 Location: Chr5:18470133-18565353 bp, - strand Genetic Position: Chr5, 8.16 cM
• Alliance: Gnai1^tm1Drs page

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was spliced into exon3. Western blot analysis confirmed the absence of gene product. (J:87423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnai1 Mutation: 15 strains or lines available

References

• Original: J:87423 Pineda VV, et al., Removal of G(ialpha1) Constraints on Adenylyl Cyclase in the Hippocampus Enhances LTP and Impairs Memory Formation. Neuron. 2004 Jan 8;41(1):153-63
• All: 8 reference(s)