Nphs2^tm1Antc
Targeted Allele Detail

Summary

• Symbol: Nphs2^tm1Antc
• Name: nephrosis 2, podocin; targeted mutation 1, Corinne Antignac
• MGI ID: MGI:3028629
• Synonyms: Nphs2^-
• Gene: Nphs2 Location: Chr1:156138297-156155605 bp, + strand Genetic Position: Chr1, 67.71 cM, cytoband G3
• Alliance: Nphs2^tm1Antc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a floxed Pgk-hygromycin cassette inserted in reverse orientation. Absence of transcript and protein product was established by Northern blot analysis and immunofluorescence experiments respectively. (J:87577)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nphs2 Mutation: 30 strains or lines available

References

• Original: J:87577 Roselli S, et al., Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Mol Cell Biol. 2004 Jan;24(2):550-60
• All: 5 reference(s)