Slc25a13^tm1Lct
Targeted Allele Detail

Summary

• Symbol: Slc25a13^tm1Lct
• Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; targeted mutation 1, Lap-Chee Tsui
• MGI ID: MGI:3028639
• Synonyms: Ctrn ^-/-
• Gene: Slc25a13 Location: Chr6:6041218-6217173 bp, - strand Genetic Position: Chr6, 2.3 cM, cytoband A1
• Alliance: Slc25a13^tm1Lct page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87578
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 347 bp region containing exon 10 was replaced with a neomycin resistance gene inserted in opposite orientation. Absence of mRNA transcript was confirmed by Northern blot and absence of protein product by Western blot analysis. (J:87578)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Slc25a13 Mutation: 179 strains or lines available

References

• Original: J:87578 Sinasac DS, et al., Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia. Mol Cell Biol. 2004 Jan;24(2):527-36
• All: 8 reference(s)