Rxfp1^tm1Jgo
Targeted Allele Detail

Summary

• Symbol: Rxfp1^tm1Jgo
• Name: relaxin/insulin-like family peptide receptor 1; targeted mutation 1, Jan A Gossen
• MGI ID: MGI:3028654
• Synonyms: Lgr7^-
• Gene: Rxfp1 Location: Chr3:79548918-79645187 bp, - strand Genetic Position: Chr3, 34.94 cM
• Alliance: Rxfp1^tm1Jgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87579
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 10 and all of exon 11 were replaced with a lacZ/Mc1-neomycin cassette so that lacZ was in frame. The substituted sequence encodes part of the seven transmembrane regions and the resulting protein product was no longer present in the cell membrane. (J:87579)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxfp1 Mutation: 53 strains or lines available

References

• Original: J:87579 Krajnc-Franken MA, et al., Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol. 2004 Jan;24(2):687-96
• All: 2 reference(s)