Ercc4^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Ercc4^tm1Fwa
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 4; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:3028660
• Synonyms: XPF^m
• Gene: Ercc4 Location: Chr16:12927548-12968481 bp, + strand Genetic Position: Chr16, 8.93 cM
• Alliance: Ercc4^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87684
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous exon 8 was replaced with a mutant version containing a nonsense mutation at codon 445. A single loxP site remained in intron 7 after the excision of a floxed neo cassette. Though the mutation was expected to generate a truncated transcript, message was undetected by RT-PCR analysis of homozygous mutant MEFs. (J:87684)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc4 Mutation: 93 strains or lines available

References

• Original: J:87684 Tian M, et al., Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol. 2004 Feb;24(3):1200-5
• All: 6 reference(s)