Bbaa16^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa16^C3H/HeN
• Name: B.burgdorferi-associated arthritis 16; C3H/HeN
• MGI ID: MGI:3028670
• QTL: Bbaa16 Location: Chr7:36280015-116416877 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa16, was identified in the (C57BL/6N X C3H/HeN)F1 X C3H/HeN backcross on Chr 7. Bbaa16 was linked to total IgG levels after infection with B.burgdorferi. It mapped from 16.0 - 53.0 cM between markers D7Mit227 and D7Mit40, LRT=20.1 accounting for 6.8% variance. [Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)