Bbaa18^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa18^C3H/HeN
• Name: B.burgdorferi-associated arthritis 18; C3H/HeN
• MGI ID: MGI:3028674
• QTL: Bbaa18 Location: Chr10:66338012-66338157 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 34.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa18, was identified in the (C57BL/6N X C3H/HeN)F1 X C57BL/6N backcross on Chr 10. Bbaa18 was linked to specific IgMlevels after infection with B.burgdorferi. It mapped to 31.5 cM with marker D10Mit130, LRT=16.7 accounting for 12.2% variance.

[Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)