Bbaa20^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Bbaa20^C3H/HeJ
• Name: B.burgdorferi-associated arthritis 20; C3H/HeJ
• MGI ID: MGI:3028676
• QTL: Bbaa20 Location: Chr6:71299605-93441074 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa20, was identified in the (C3H/HeJ X BALB/cAnN)F1 X BALB/cAnN backcross on Chr 6. Bbaa20 was linked to IgG levels after infection with B.burgdorferi. It mapped from 30.5 - 38.5 cM between markers D6Mit16 and D6Mit102, LRT=18.9 accounting for 14.8% variance.

The reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross also confirmed the previously identified Bbaa5 QTL on Chr 6. Using CIM Bbaa5 linked to specific IgM, at 71.6 cM with marker D6Mit200, LRT=24.4 and total IgM from 43.0 -67.0 cM between marker D6Mit230 and D6Mit59, LRT=29.2. [Table 3.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)