Bbaa23^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa23^C3H/HeN
• Name: B.burgdorferi-associated arthritis 23; C3H/HeN
• MGI ID: MGI:3028678
• QTL: Bbaa23 Location: Chr4:102781167-102781279 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 47.21 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:70360)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

In the (C57BL/6N X C3H/HeN)F1 X C57BL/6N backcross a novel QTL, Bbaa13 was identified on

on Chr 4. Bbaa13 was linked to ankle swelling at 6.5 cM with marker D4Mit264, LRT=18.6 accounting for 10.7% of variance. [Table 2.]

In the reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross another novel, Chr 4 QTL, Bbaa23, was identified. Bbaa23 is linked to the number of B.burgdorferi in heart tissue post-infection. It mapped to 49.6 cM with marker D4Mit219, LRT=21.6 accounting for 11.2% of variation. [Table 2.]

The reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross also confirmed the previoulsy identified Bbaa1 QTL on Chr 4. Using CIM Bbaa1, linked to ankle swelling, mapped to 28.6 cM with marker D4Mit139, LRT=19.6. [Table 3.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:70360 Mikola MK, et al., Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment. J Endocrinol. 2001 Jul;170(1):79-90
• All: 1 reference(s)