Adam19^{Gt(Betageo)1Bbl}
Gene trapped Allele Detail

Summary

• Symbol: Adam19^{Gt(Betageo)1Bbl}
• Name: ADAM metallopeptidase domain 19; gene trap 1, Carl P Blobel
• MGI ID: MGI:3028702
• Synonyms: adam19^-
• Gene: Adam19 Location: Chr11:45946819-46038170 bp, + strand Genetic Position: Chr11, 27.54 cM, cytoband A5-B1.1
• Alliance: Adam19^{Gt(Betageo)1Bbl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Sequence encoding the carboxyl cysteine-rich domain was disrupted by a secretory gene trap vector containing a Beta-geo cassette. The insertion putatively interferes with proper protein folding resulting in the retention and subsequent degradation of the mutant protein in the enodplasmic reticulum. (J:87592)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam19 Mutation: 78 strains or lines available

References

• Original: J:87592 Zhou HM, et al., Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol. 2004 Jan;24(1):96-104
• All: 3 reference(s)