Pik3r1^tm1Khn
Targeted Allele Detail

Summary

• Symbol: Pik3r1^tm1Khn
• Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, C Ronald Kahn
• MGI ID: MGI:3028729
• Synonyms: p55alpha^-/p50alpha^-
• Gene: Pik3r1 Location: Chr13:101817269-101904725 bp, - strand Genetic Position: Chr13, 53.92 cM
• Alliance: Pik3r1^tm1Khn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87598
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1B and 1C were replaced by an inverted neomycin cassette. Western blot analysis confirmed the absence of p50alpha and p55alpha products without affecting p85alpha product (J:87598)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3r1 Mutation: 56 strains or lines available

References

• Original: J:87598 Chen D, et al., p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol. 2004 Jan;24(1):320-9
• All: 3 reference(s)