Pnpla6^tm1Mos
Targeted Allele Detail

Summary

• Symbol: Pnpla6^tm1Mos
• Name: patatin-like phospholipase domain containing 6; targeted mutation 1, Markus Moser
• MGI ID: MGI:3028797
• Gene: Pnpla6 Location: Chr8:3565384-3594267 bp, + strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pnpla6^tm1Mos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87675
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing IRES-lacZ and neo was inserted at codon 397, upstream of the carboxyl-terminal catalytic domain. Western blot analysis of lysates from cultured cells indicated an absence of protein of in homozygous mutant embyros. A 50% reduction of esterase activity in tissue homogenates obtained from heterozygous mutant mice indicated functional ablation. (J:87675)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla6 Mutation: 63 strains or lines available

References

• Original: J:87675 Moser M, et al., Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol Cell Biol. 2004 Feb;24(4):1667-79
• All: 1 reference(s)