Emilin1^tm1Gmb
Targeted Allele Detail

Summary

• Symbol: Emilin1^tm1Gmb
• Name: elastin microfibril interfacer 1; targeted mutation 1, Giorgio M Bressan
• MGI ID: MGI:3028845
• Synonyms: Emi1^-
• Gene: Emilin1 Location: Chr5:31070746-31078621 bp, + strand Genetic Position: Chr5, 16.9 cM
• Alliance: Emilin1^tm1Gmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87574
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-PGK-neomycin cassette was inserted into exon 1. Northern blot and RT-PCR analysis demonstrated absence of mRNA. Protein product was undetectable in tissue sections by immunofluorescence. (J:87574)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emilin1 Mutation: 43 strains or lines available

References

• Original: J:87574 Zanetti M, et al., EMILIN-1 deficiency induces elastogenesis and vascular cell defects. Mol Cell Biol. 2004 Jan;24(2):638-50
• All: 12 reference(s)