Tg(aP2-SREBF1c)9884Reh
Transgene Detail

Summary

• Symbol: Tg(aP2-SREBF1c)9884Reh
• Name: transgene insertion 9884, Robert E Hammer
• MGI ID: MGI:3028848
• Synonyms: aP2-SREBP-1c436
• Transgene: Tg(aP2-SREBF1c)9884Reh Location: unknown
• Alliance: Tg(aP2-SREBF1c)9884Reh page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(aP2-SREBF1c)9884Reh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

• Mutation details: Sequence encoding residues 1 through 436 of human nuclear sterol regulatory element binding protein-1c (SREBF1c) was adjoined to 5.4 kb of the mouse adipose-specific enhancer/promoter of aP2. SREBF1c sequence encoding the membrane-attachment domain was not included in the construct, permitting the expressed component to enter the nucleus without a requirement for proteolysis. (J:50770)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line was generated from founder number 988-4.

References

• Original: J:50770 Shimomura I, et al., Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 1998 Oct 15;12(20):3182-94
• All: 16 reference(s)