Elk1^tm1Nor
Targeted Allele Detail

Summary

• Symbol: Elk1^tm1Nor
• Name: ELK1, member of ETS oncogene family; targeted mutation 1, Alfred Nordheim
• MGI ID: MGI:3028871
• Synonyms: Elk-1^-, Elk-1⁽¹³⁷⁾
• Gene: Elk1 Location: ChrX:20799634-20816847 bp, - strand Genetic Position: ChrX, 16.45 cM, cytoband A1-A3
• Alliance: Elk1^tm1Nor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87597
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, RMCE-ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a hygromycin-thymidine kinase cassette which was flanked by non-identical FRT recognition sites. Absence of mRNA transcripts was confirmed by RT-PCR while protein specific assays confirmed that no protein product was present. (J:87597)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elk1 Mutation: 8 strains or lines available

References

• Original: J:87597 Cesari F, et al., Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol Cell Biol. 2004 Jan;24(1):294-305
• All: 11 reference(s)