Matn3^tm1Asz
Targeted Allele Detail

Summary

• Symbol: Matn3^tm1Asz
• Name: matrilin 3; targeted mutation 1, Attila Aszodi
• MGI ID: MGI:3028891
• Synonyms: Matn3^-
• Gene: Matn3 Location: Chr12:8997929-9022028 bp, + strand Genetic Position: Chr12, 3.96 cM
• Alliance: Matn3^tm1Asz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87676
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin cassette was inserted into exon 1 causing the partial deletion of the promoter region and the 5' part of exon 1 containing the ATG start site. Absence of protein product was demonstrated by immunohistochemistry on tissue sections at E13.5 as well as in situ hybridization to confirm the absence of mRNA transcripts. (J:87676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Matn3 Mutation: 26 strains or lines available

References

• Original: J:87676 Ko Y, et al., Matrilin-3 is dispensable for mouse skeletal growth and development. Mol Cell Biol. 2004 Feb;24(4):1691-9
• All: 5 reference(s)