Pou2f2^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Pou2f2^tm1Bal
• Name: POU domain, class 2, transcription factor 2; targeted mutation 1, David Baltimore
• MGI ID: MGI:3028896
• Synonyms: oct-2^-
• Gene: Pou2f2 Location: Chr7:24790111-24879292 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Pou2f2^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4555
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A nonsense mutation was introduced in sequence encoding the POU-specific domain via homologous recombination. The stop codon was generated upstream of the POU homeo domain, into which a PGK-neo cassette was inserted. (J:4555)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou2f2 Mutation: 29 strains or lines available

References

• Original: J:4555 Corcoran LM, et al., Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 1993 Apr;7(4):570-82
• All: 12 reference(s)