Trp53^tm1Snj
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Snj
• Name: transformation related protein 53; targeted mutation 1, Stephen N Jones
• MGI ID: MGI:3028920
• Synonyms: p53Ala18, p53^S18A
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Snj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87687
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mutation was introduced into exon 2 resulting in serine codon 18 (AGC) to change to alanine (GCC) (p.S18A). A loxP site flanked neomycin resistance gene cassette was inserted into intron 1. Subsequent excision of the neo cassette occurred in the F1 progeny of chimeric males as the result of expression of the protamine-Cre transgene which is endogenous to the PC3 ES cells used. (J:87687)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Snj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 239 strains or lines available

References

• Original: J:87687 Sluss HK, et al., Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol. 2004 Feb;24(3):976-84
• All: 7 reference(s)