Anxa2^tm1Kah
Targeted Allele Detail

Summary

• Symbol: Anxa2^tm1Kah
• Name: annexin A2; targeted mutation 1, Katherine A Hajjar
• MGI ID: MGI:3028929
• Synonyms: A2^-, Anxa2^-
• Gene: Anxa2 Location: Chr9:69360978-69399074 bp, + strand Genetic Position: Chr9, 38.58 cM
• Alliance: Anxa2^tm1Kah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87621
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin resistance gene inserted in antisense orientation. Reduced quantities of a smaller than normal sized mRNA were detectable in heart and lung extracts by Northern blot analysis. However, no immunodetectable protein could be identified by Western blot analysis. (J:87621)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Anxa2 Mutation: 49 strains or lines available

References

• Original: J:87621 Ling Q, et al., Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest. 2004 Jan;113(1):38-48
• All: 22 reference(s)