Cited1^tm1Dunw
Targeted Allele Detail

Summary

• Symbol: Cited1^tm1Dunw
• Name: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1; targeted mutation 1, Sally L Dunwoodie
• MGI ID: MGI:3028946
• Synonyms: Cited1^neo
• Gene: Cited1 Location: ChrX:101290987-101295787 bp, - strand Genetic Position: ChrX, 45.25 cM
• Alliance: Cited1^tm1Dunw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87595
• Parent Cell Line: E14.2 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was deleted via cre-mediated recombination of the loxP sites inserted by homologous recombination. Although the targeting vector included an frt-flanked neo cassette and sequence encoding GFP, GFP expression was undetected. Sequence analysis of the targeted locus identified a single base insertion, resulting in a frameshift mutation in the inserted sequence. (J:87595)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cited1^tm1Dunw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cited1 Mutation: 6 strains or lines available

References

• Original: J:87595 Rodriguez TA, et al., Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004 Jan;24(1):228-44
• All: 5 reference(s)