Slc8a3^tm1Sso
Targeted Allele Detail

Summary

• Symbol: Slc8a3^tm1Sso
• Name: solute carrier family 8 (sodium/calcium exchanger), member 3; targeted mutation 1, Sophie Sokolow
• MGI ID: MGI:3028976
• Synonyms: Ncx3^-/-
• Gene: Slc8a3 Location: Chr12:81244689-81379954 bp, - strand Genetic Position: Chr12, 37.44 cM
• Alliance: Slc8a3^tm1Sso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87615
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted in exon 2. Absence of mRNA was confirmed by hybridization assay and by RT-PCR. Absence of protein was demonstrated immunologically and by Western blot analysis. (J:87615)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a3 Mutation: 65 strains or lines available

References

• Original: J:87615 Sokolow S, et al., Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J Clin Invest. 2004 Jan;113(2):265-73
• All: 11 reference(s)