Rhog^tm1Tnr
Targeted Allele Detail

Summary

• Symbol: Rhog^tm1Tnr
• Name: ras homolog family member G; targeted mutation 1, Martin Turner
• MGI ID: MGI:3029009
• Synonyms: RhoG^-, Rhog^tm1Evi
• Gene: Rhog Location: Chr7:101888330-101899325 bp, - strand Genetic Position: Chr7, 54.71 cM, cytoband F1
• Alliance: Rhog^tm1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87580
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 which includes the entire open reading frame was replaced with a neomycin resistance gene inserted in reverse orientation. Northern blot analysis confirmed the absence of mRNA transcript. (J:87580)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rhog Mutation: 7 strains or lines available

References

• Original: J:87580 Vigorito E, et al., Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol. 2004 Jan;24(2):719-29
• All: 11 reference(s)