Capn5^tm1Nde
Targeted Allele Detail

Summary

• Symbol: Capn5^tm1Nde
• Name: calpain 5; targeted mutation 1, T Neil Dear
• MGI ID: MGI:3029041
• Synonyms: Capn5^lacZ
• Gene: Capn5 Location: Chr7:97770766-97827481 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Capn5^tm1Nde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87678
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ-MC1-Neomycin cassette was inserted in exon 4 in the midst of the sequence coding for the protease active site. No mRNA transcript was detectable by Northern blot analysis of brain or liver RNA using a cDNA probe located downstream of the insertion site. (J:87678)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Capn5 Mutation: 48 strains or lines available

References

• Original: J:87678 Franz T, et al., Capn5 is expressed in a subset of T cells and is dispensable for development. Mol Cell Biol. 2004 Feb;24(4):1649-54
• All: 1 reference(s)