Trpv1^tm1Jbd
Targeted Allele Detail

Summary

• Symbol: Trpv1^tm1Jbd
• Name: transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1, John B Davis
• MGI ID: MGI:3029186
• Synonyms: TRPV1 -, VR1^-
• Gene: Trpv1 Location: Chr11:73125118-73152068 bp, + strand Genetic Position: Chr11, 45.25 cM, cytoband B3
• Alliance: Trpv1^tm1Jbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62074
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encoding amino acids 460 through 555 was replaced with a neomycin selection cassette inserted by homologous recombination. The deletion was designed to eliminate transmembrane domains 2 through 4. (J:62074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv1 Mutation: 60 strains or lines available

References

• Original: J:62074 Davis JB, et al., Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature. 2000 May 11;405(6783):183-7
• All: 35 reference(s)