Ntsr1^tm1Hmno
Targeted Allele Detail

Summary

• Symbol: Ntsr1^tm1Hmno
• Name: neurotensin receptor 1; targeted mutation 1, Hiroshi Maeno
• MGI ID: MGI:3029204
• Gene: Ntsr1 Location: Chr2:180141769-180186772 bp, + strand Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
• Alliance: Ntsr1^tm1Hmno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87872
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes the fifth and sixth transmembrane domains, was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis. (J:87872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntsr1 Mutation: 31 strains or lines available

References

• Original: J:87872 Maeno H, et al., Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception. Brain Res. 2004 Feb 13;998(1):122-9
• All: 5 reference(s)