Aco1^tm1Roua
Targeted Allele Detail

Summary

• Symbol: Aco1^tm1Roua
• Name: aconitase 1; targeted mutation 1, Tracey A Rouault
• MGI ID: MGI:3029223
• Synonyms: IRP1-
• Gene: Aco1 Location: Chr4:40143081-40198338 bp, + strand Genetic Position: Chr4, 20.24 cM
• Alliance: Aco1^tm1Roua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87889
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin resistance gene was inserted into exon 13. Protein product was undetectable by Western blot analysis and cytosolic aconitase activity was lost in homozygous mice. (J:87889)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aco1 Mutation: 51 strains or lines available

References

• Original: J:87889 Meyron-Holtz EG, et al., Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 2004 Jan 28;23(2):386-95
• All: 12 reference(s)