Trigq1^KK
QTL Variant Detail

Summary

• QTL variant: Trigq1^KK
• Name: triglyceride QTL 1; KK
• MGI ID: MGI:3029263
• Synonyms: Trigq1^KK-Ay
• QTL: Trigq1 Location: Chr9:61428174-61428262 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 33.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: KK

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87328

Authors reanalyzed a (C57BL/6J x KK-A^y)F2 cross to confirm QTLs associated with plasma cholesterol and triglyceride levels. A new (KK x RR)F2 cross was also analyzed at 82 microsatellite markers at an average resolution of 19.5 cM for the same traits. Parental strain KK-A^y exhibits increased plasma cholesterol and triglycerides compared to parental strains C57BL/6J and RR. The RR strain exhibits a slight tendency towards obesity.

In the (C57BL/6J x KK-A^y)F2 cross the following QTLs were confirmed:Cq1, Cq2, and Cq3. A new QTL associated with plasma cholesterol level, Cq4, was identified at 9 cM on mouse Chromosome 9 with LOD=4.4 at D9Mit90. KK-derived alleles confer increased cholesterol at Cq4 with an additive mode of inheritance. Candidate genesmapping near Cq4 include Ldlr, Apoa1, Apoa4, Apoa5, Apoc3, and Cyp11a1. Cq4 maps near an obesity QTL named Obq5.

A novel QTL associated with triglyceride levels was also identified in the reanalysis of the (C57BL/6J x KK-A^y)F2 cross. Tgq1 mapped to 33 cM on mouse Chromosome 9 with LOD=5 at D9Mit163. Candidate genes for Tgq1 include Apoc3, Apoa5, and Lipc.

In the (KK x RR)F2 cross novel QTLs Cq5 and Tgq2 were identified. Cq5 maps to 28 cM on mouse Chromosome 9 with LOD=5.6 at D9Mit229. The KK-derivedallele at Cq5 confers increased plasma cholesterol consistent with an additive or recessive mode of inheritance. Cq5 maps to the same general vicinity as Cq4 and has candidate genes in common.

Tgq2 maps to 30 cM on mouse Chromosome 8 with LOD=4.7 at D8Mit205. KK-derived alleles confer increased triglyceride levels at Tgq2 with an additive or recessive mode of inheritance. Candidate genes mapping near Tgq2 include Cpe, Lpl, and Ucp1. Lpl appears to be an attractive candidate gene since transgenic mice overexpressing Lpl exhibit decreased triglyceride levels while Lpl knockout animals exhibit elevated triglycerides. Tgq2 maps near previously identified QTLs Giq1 (glucose intolerance) and Tg-1 (triglyceride 1, Shike et al, 2001).

References

• Original: J:87328 Suto J, et al., Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice. Biochem Genet. 2003 Oct;41(9-10):325-41
• All: 1 reference(s)