En1^tm2(cre)Gld
Targeted Allele Detail

Summary

• Symbol: En1^tm2(cre)Gld
• Name: engrailed 1; targeted mutation 2, Martyn Goulding
• MGI ID: MGI:3029756
• Synonyms: En1^Cre, En1^KICre
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm2(cre)Gld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87771
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• En1^tm2(cre)Gld expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	En1 (MGI:95389)

• Mutation details: A cassette containing cre followed by PGK-neo was inserted into exon 1 of the endogenous locus, replacing the start codon and sequence encoding the first 72 amino acids. Cre recombinase is expressed via the endogenous promoter. (J:87771)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	En1 (mouse) Summary of all recombinase alleles driven by En1. Alliance mouse En1 gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 34 strains or lines available

References

• Original: J:87771 Sapir T, et al., Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development. J Neurosci. 2004 Feb 4;24(5):1255-64
• All: 18 reference(s)