Adar^tm1Phs
Targeted Allele Detail

Summary

• Symbol: Adar^tm1Phs
• Name: adenosine deaminase, RNA-specific; targeted mutation 1, Peter H Seeburg
• MGI ID: MGI:3029789
• Synonyms: adar1^-, adar1^Delta7-9
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^tm1Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87715
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 7 through 9 was deleted by cre mediated recombination of an upstream floxed neo cassette and a downstream single loxP site. A single loxP site remains in intron 6. The deleted region encodes residues 707 through 870 of the interferon-inducible form of ADAR. (J:87715, J:142338)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 72 strains or lines available

References

• Original: J:87715 Hartner JC, et al., Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1. J Biol Chem. 2004 Feb 6;279(6):4894-902
• All: 4 reference(s)