Adar^tm2Phs
Targeted Allele Detail

Summary

• Symbol: Adar^tm2Phs
• Name: adenosine deaminase, RNA-specific; targeted mutation 2, Peter H Seeburg
• MGI ID: MGI:3029862
• Synonyms: adar1^-, adar1^Delta2-13
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^tm2Phs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87715
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 2 through 13 was replaced with a neo cassette inserted by homologous recombination. The deleted region encodes residues 11 through 1054, which encompass the all three dsRNA-binding domains, two putative Z-DNA-binding domains, and the majority of the catalytic domain. (J:87715)

Expression

In Mice Carrying this Mutation:	36 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 72 strains or lines available

References

• Original: J:87715 Hartner JC, et al., Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1. J Biol Chem. 2004 Feb 6;279(6):4894-902
• All: 6 reference(s)