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Runx1tm2(Runx1)Toku
Targeted Allele Detail
Summary
Symbol: Runx1tm2(Runx1)Toku
Name: runt related transcription factor 1; targeted mutation 2, Tsukasa Okuda
MGI ID: MGI:3029983
Synonyms: AML1WT
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm2(Runx1)Toku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87697
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Other
 
Mutation detailsA cDNA encoding the entire RUNX1 protein was inserted into exon 4 of the endogenous locus via homologous recombination. Semiquantitative RT-PCR analysis of splenic and thymic message showed the levels of mutant transcript in homozygous mutant mice to be similar to the levels of normal transcript in wild-type mice. (J:87697)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  34 strains or lines available
References
Original:  J:87697 Nishimura M, et al., VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood. 2004 Jan 15;103(2):562-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory