Runx1tm2(Runx1)Toku
Targeted Allele Detail
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Symbol: |
Runx1tm2(Runx1)Toku |
Name: |
runt related transcription factor 1; targeted mutation 2, Tsukasa Okuda |
MGI ID: |
MGI:3029983 |
Synonyms: |
AML1WT |
Gene: |
Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
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Alliance: |
Runx1tm2(Runx1)Toku page
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Germline Transmission: |
Earliest citation of germline transmission:
J:87697
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Other
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Mutation details: A cDNA encoding the entire RUNX1 protein was inserted into exon 4 of the endogenous locus via homologous recombination. Semiquantitative RT-PCR analysis of splenic and thymic message showed the levels of mutant transcript in homozygous mutant mice to be similar to the levels of normal transcript in wild-type mice.
(J:87697)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Runx1 Mutation: |
34 strains or lines available
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Original: |
J:87697 Nishimura M, et al., VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development. Blood. 2004 Jan 15;103(2):562-70 |
All: |
1 reference(s) |
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