Avpr1b^tm1Gzt
Targeted Allele Detail

Summary

• Symbol: Avpr1b^tm1Gzt
• Name: arginine vasopressin receptor 1B; targeted mutation 1, Gozoh Tsujimoto
• MGI ID: MGI:3029988
• Synonyms: V1bR^-, V1bR KO
• Gene: Avpr1b Location: Chr1:131526977-131539738 bp, + strand Genetic Position: Chr1, 57.09 cM, cytoband E4
• Alliance: Avpr1b^tm1Gzt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87707
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.5-kb region including the first exon and part of the first intron of the gene was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:87707)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Avpr1b Mutation: 33 strains or lines available

References

• Original: J:87707 Tanoue A, et al., The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J Clin Invest. 2004 Jan;113(2):302-9
• All: 14 reference(s)