Tg(Pdx1-cre)6Tuv
Transgene Detail

Summary

• Symbol: Tg(Pdx1-cre)6Tuv
• Name: transgene insertion 6, David A Tuveson
• MGI ID: MGI:3032531
• Synonyms: Pdx1-cre, PDX-1-Cre, Pdx1-Cre^Tg, Pdx1-Cre^Tuv, Tg(Ipf1-cre)1Tuv, Tg(Ipf1-cre)6Tuv
• Transgene: Tg(Pdx1-cre)6Tuv Location: unknown Genetic Position: Chr8, Syntenic
• Alliance: Tg(Pdx1-cre)6Tuv page

Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm Tg(Pdx1-cre)6Tuv/? pancreata display extensive loss of exocrine tissue

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pdx1-cre)6Tuv expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pdx1

• Mutation details: The transgenic construct is composed of a Cre recombinase coding sequence under the control of the Pdx1 promoter. Cre expression is thus directed to islet cells of the pancreas. Line 6 was inserted into chromosome 8 about 48 kb upstream of Zfp423 (chr8:90,531,639; NCBI37/mm9) with elements of human ACTB 3'UTR and polyA signal, and a 1.5 kb genomic duplication at the integration site. (J:87973, J:240920)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (species not specified) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

23 assay results 13 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pdx1-cre)6Tuv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:87973 Hingorani SR, et al., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50
• All: 474 reference(s)