Syn1^tm2Noh
Targeted Allele Detail

Summary

• Symbol: Syn1^tm2Noh
• Name: synapsin I; targeted mutation 2, Nobutaka Hirokawa
• MGI ID: MGI:3032535
• Synonyms: A-30
• Gene: Syn1 Location: ChrX:20726750-20787157 bp, - strand Genetic Position: ChrX, 16.37 cM, cytoband A1-A4
• Alliance: Syn1^tm2Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30400
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-galactosidase/neomycin gene fusion selection cassette replaced part of exon 1 and intron 1. Western blot analysis confirmed the absence of encoded protein in brain extracts derived from homozygous mice. (J:30400)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syn1 Mutation: 22 strains or lines available

References

• Original: J:30400 Takei Y, et al., Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system. J Cell Biol. 1995 Dec;131(6 Pt 2):1789-800
• All: 2 reference(s)