Pgr^tm1Lyd
Targeted Allele Detail

Summary

• Symbol: Pgr^tm1Lyd
• Name: progesterone receptor; targeted mutation 1, John P Lydon
• MGI ID: MGI:3032652
• Synonyms: PRKO^lacZ, PR^lacZ
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^tm1Lyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79968
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene was inserted in frame within exon 1 followed by a PGK-neomycin resistance gene. This replaced sequence from 356bp to 724bp downsteam of the initiator codon for the "B" isoform. As a result, the coding sequence for a 122aa fragment was removed including the initiation codon for the "A" isoform. Care was taken not to disrupt the estrogen response elements. (J:79968)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 75 strains or lines available

References

• Original: J:79968 Ismail PM, et al., A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol. 2002 Nov;16(11):2475-89
• All: 14 reference(s)