Fasl^tm1Lest
Targeted Allele Detail

Summary

• Symbol: Fasl^tm1Lest
• Name: Fas ligand; targeted mutation 1, Matthieu Levi-Strauss
• MGI ID: MGI:3032852
• Synonyms: CD95flox, FasL^fl
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm1Lest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and a single loxP site were inserted in the 5' UTR and the 3' UTR, respectively, via homologous recombination of a targeting vector. (J:87990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 37 strains or lines available

References

• Original: J:87990 Karray S, et al., Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J Immunol. 2004 Feb 15;172(4):2118-25
• All: 10 reference(s)