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Ightm1Tim
Targeted Allele Detail
Summary
Symbol: Ightm1Tim
Name: immunoglobulin heavy chain complex; targeted mutation 1, Tim Manser
MGI ID: MGI:3032982
Synonyms: HKIR R55
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88410
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsJ1 through J4 were replaced with a neomycin resistance cassette followed by the 36-65 VDJ fragment in which an Asn to Arg mutation has been introduced for codon 55. (J:88410)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:88410 Notidis E, et al., Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development. Immunity. 2002 Sep;17(3):317-27
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory