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Ightm2Tim
Targeted Allele Detail
Summary
Symbol: Ightm2Tim
Name: immunoglobulin heavy chain complex; targeted mutation 2, Tim Manser
MGI ID: MGI:3032983
Synonyms: HKI65
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87624
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
    J1 through J4 were replaced with a neomycin resistance cassette followed by the 36-65VDJ fragment. (J:87624)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:87624 Heltemes-Harris L, et al., Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype. J Immunol. 2004 Jan 15;172(2):823-33
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory