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Alcp2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Alcp2C57BL/6J
Name: alcohol preference locus 2, female specific; C57BL/6J
MGI ID: MGI:3032990
QTL: Alcp2  Location: Chr11:72209796-84731462 bp  Genetic Position: Chr11, cM position of peak correlated region/allele: 44.0 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased alcohol consumption compared to DBA/2J. (J:33277)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Alcp2 appears to exhibit paternal imprinting. Increased alcohol consumption is observed when homozygous female animals are derived from C57BL/6J fathers.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:33277

Backcross progeny from crosses between (C57BL/6J x DBA/2J)F1 females x C57BL/6J males (N = 262) and C57BL/6J females x (C57BL/6J x DBA/2J)F1 males (N = 73) were analyzed for alcohol consumption. The difference in alcohol consumption between male and female backcross progeny is significant at a P value of 0.00004, therefore sexes were analyzed separately using chi-square analysis to find quantitative trait loci (QTL). A region of mouse Chromsome 11 bounded proximally by D11Mit219 and distally by D11Mit195was associated with alcohol consumption in female mice and given the symbol Alcp2. The genetic distances between the informative microsatellite loci were as follows: D11Mit140 - 13 cM - D11Mit219 - 3 cM - D11Mit40 - 5 cM - D11Mit195 - 12 cM - D11Mit199. In addition it was observed that the Alcp2 phenotype is significantly expressed only in female backcross progeny derived from a paternal C57BL/6J.

Female animals having a C57BL/6J father and are homozygous for C57BL/6J-derived alleles at Alcp2 exhibit increased alcohol consumption.

References
Original:  J:33277 Melo JA, et al., Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. Nat Genet. 1996 Jun;13(2):147-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory