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Asthm1BALB/c
QTL Variant Detail
Summary
QTL variant: Asthm1BALB/c
Name: asthma 1; BALB/c
MGI ID: MGI:3032996
QTL: Asthm1  Location: unknown  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  BALB/c
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased airway responsiveness compared to BP2. (J:54405)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:54405

217 (BP2 x BALB/c)F2 animals were typed for 180 microsatellite markers to identify QTLs associated with asthma phenotypes, such as bronchial airway responsiveness and eosinophil infiltration. Biozzi BP2 mice exhibit symptoms similar to human allergic asthma following induction with ovalbumin whereas inbred strain BALB/c is resistant to asthma-like symptoms. Loci significantly associated with bronchial airway responsiveness are Asthm1 (asthma) mapping to mouse chromosome 10 with LOD = 3.8 at 44 cM and Asthm2 mapping to mouse chromosome 11 with LOD = 3.65 at 69 cM. BALB/c-derived alleles contribute to increased airway responsiveness at Asthm1 while BP2-derived alleles contribute to increased airway responsiveness at Asthm2. Suggestive loci linked to asthmaphenotypes map to mouse chromosome 9 (LOD = 2.5 at 18 cM), mouse chromosome 11 (LOD = 3.4 at 7 cM), and mouse chromosome 17 (LOD = 2.1 at 10 cM). BALB/c-derived alleles contribute to increased airway responsiveness at the chromosome 9 and chromosome 17 loci, and BP2-derived alleles contribute to increased eosinophil counts at the chromosome 11 locus. The chromosome 17 locus is near Bhr3, a QTL for bronchial hyperresponsiveness (DeSanctis, J:29231).

References
Original:  J:54405 Zhang Y, et al., A genome-wide screen for asthma-associated quantitative trait loci in a mouse model of allergic asthma. Hum Mol Genet. 1999 Apr;8(4):601-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory